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Article: Correlation between adsorption induced changes in protein structure and platelet adhesion. (South Carolina Academy of Sciences Abstracts).(Brief Article)
- Article from:
- Bulletin of the South Carolina Academy of Science
- Article date:
- January 1, 2003
- Author:
CopyrightCOPYRIGHT 2003 South Carolina Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Thrombus formation and platelet activation represent two of the most serious problems related to the biocompatibility of biomaterials in blood-contact applications. While it is believed that denaturation of adsorbed proteins at the implant surface directly leads to the adhesion and activation of platelets and subsequent thrombus formation, no data exists to directly correlate these two phenomena. The objective of our study was therefore to use CD spectroscopy to directly measure the change in adsorbed protein structure and investigate its relationship to platelet adhesion. Thin films of polyethylene and polypropylene were surface modified using liquid-phase sulfonation, a ...