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Article: Genetic Regulator of Lifespan Identified; Gene That Extends Lifespan in Yeast Points to Paradigm Shift in Longevity Research; May Explain Life Extension via Calorie Restriction.
- Article from:
- Ascribe Higher Education News Service
- Article date:
- May 7, 2003
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Byline: Harvard University Medical School
BOSTON, May 7 (AScribe Newswire) -- Researchers at Harvard Medical School (HMS) have discovered that a gene in yeast is a key regulator of lifespan. The gene, PNC1, is the first that has been shown to respond specifically to environmental factors known to affect lifespan in many organisms. A team led by David Sinclair, assistant professor of pathology at HMS, found that PNC1 is required for the lifespan extension that yeast experience under calorie restriction. A yeast strain with five copies of PNC1 lives 70 percent longer than the wild type strain, the longest lifespan extension yet reported in that organism. Their ...