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Article: Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors described.
- Article from:
- Drug Week
- Article date:
- May 16, 2003
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2003 MAY 16 - (NewsRx.com & NewsRx.net) -- Researchers at the National Istitutes of Health report the first use of azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
"Aryl beta-diketo acids (ADK) comprise a general class of potent HIV-1 integrase (IN) inhibitors, which can exhibit selective inhibition of strand transfer reactions in extracellular recombinant IN assays and provide potent antiviral effects in HIV-infected cells.
"Recent studies have shown that polycyclic aryl or aryl rings bearing aryl-containing substituents are components of potent members of this class. Reported herein is the first use of azido functionality as an aryl ...