Article: Riboflavin: the dose makes the poison. (Guest Editorial).

Riboflavin, or vitamin B-2, is an essential dietary component required in small amounts for many functions, including regenerating the vital antioxidant glutathione. Dietary riboflavin that is not being utilized in riboflavin-dependent enzymes exists as free riboflavin. When we consume riboflavin in excess of this requirement, there is a dramatic increase in blood, tissue, and urine levels of free riboflavin.

Normally the body contains low levels of free riboflavin, but it's easy to get abnormally high levels of riboflavin, simply because many of the supplements available in today's marketplace contain an excess amount of riboflavin. This is a particular concern ...

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