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Article: Unnatural amino acids result from re-engineered cysteine-biosynthetic pathway.
- Article from:
- Biotech Week
- Article date:
- June 4, 2003
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2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists with Wacker Chemical GMBH, Munich, Germany, have used a fermentation-based approach for biosynthesis of unnatural amino acids after re-engineering the cysteine-biosynthetic pathway in Escherichia coli.
"There is an increasing demand for peptide-mimicking molecules to modulate the interactions between proteins of pharmaceutical and agrochemical interest and their target polypeptides. Unnatural L-alpha-amino acids differing from the 20 naturally proteinogenic amino acids only in their side chain are ideal for this purpose, but their chemical synthesis is complex," wrote T.H.P. Maier and colleagues.
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