|
|
Article: The Col3a1 promoter activates procollagen genes in dermal fibroblasts.
- Article from:
- Health & Medicine Week
- Article date:
- June 2, 2003
CopyrightCOPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2003 JUN 2 - (NewsRx.com & NewsRx.net) -- The Col3a1 promoter activates procollagen genes in dermal fibroblasts.
"Transient transfection experiments into Tsk2l+ and normal dermal fibroblasts were performed using four successively shorter Col3a1 promoter deletion constructs: #103, #110, #114, and #120 fused to the chloramphenicol-acetyl-transferase (CAT) reporter gene," scientists in the United States reported.
"The transcriptional activity in Tsk2l+ and normal dermal fibroblasts driven by the three longer constructs was equal. With the shortest construct, #120 (-96 to +16 bp) the transcriptional activity in Tsk2l+ fibroblasts was 25 times higher than in ...