Article: Tarceva -- erlotinib HCl -- Shows Encouraging Safety Profile and Activity in Phase I Clinical Study in Patients with Malignant Glioma.

Business Editors/Health/Medical Writers

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CHICAGO--(BUSINESS WIRE)--May 31, 2003

Genentech and OSI Pharmaceuticals Moving Forward

to Initiate Phase II Study

Genentech, Inc. (NYSE:DNA) and OSI Pharmaceuticals, Inc. (NASDAQ:OSIP) announced encouraging results from a Phase I clinical study of Tarceva(TM) (erlotinib HCl) in patients with malignant glioma (brain cancer). Tarceva is designed to inhibit the tyrosine kinase activity of the HER1/EGFR signaling pathway inside the cell, which may block tumor cell growth.

"We are very encouraged by the safety profile and the response rates seen in this Phase I study in ...

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