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Article: The bystander effect of TRAIL gene therapy relies on cell-to-cell contact.
- Article from:
- Biotech Week
- Article date:
- July 16, 2003
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2003 JUL 16 - (NewsRx.com & NewsRx.net) -- The bystander effect of TRAIL gene therapy relies on cell-to-cell contact.
"We have previously reported that direct transfer of the TNF-related apoptosis-inducing ligand (TRAIL) gene resulted in an apoptotic bystander effect, and that this bystander effect was not transferable with cell culture media. To further characterize its mechanism we tested the bystander effect of TRAIL in the human ovarian cancer cell line DOV13, human lung cancer cell line A549, human hepatoma cell line Hepa G2, human breast cancer cell line MDA-MB231 and human colon cancer cell lines Lovo and DLDL," wrote X.F. Huang and colleagues, University ...