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Article: Keratin 8 and 18 mutations heighten susceptibility to liver cancer formation.
- Article from:
- Biotech Week
- Article date:
- July 16, 2003
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2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Keratin 8 and 18 mutations heighten susceptibility to liver cancer formation.
"Keratin 8 and 18 (K8/K18) mutations are found in patients with cryptogenic cirrhosis, but the role of keratin mutations in noncryptogenic cirrhosis and the incidence of keratin mutations in the general population are not known," researchers in the United States report.
"We screened for K8/K18 mutations in genomic DNA isolated from 314 liver explants of patients who primarily had noncryptogenic cirrhosis, and from 349 blood bank volunteers. Seven unique K8/K18 mutations were found in 11 independent patients with biliary atresia, ...