|
|
Article: Hypoxia-inducible factor-1 alpha alters tumor sensitivity through DNA repair.
- Article from:
- Cancer Weekly
- Article date:
- July 15, 2003
CopyrightCOPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2003 JUL 15 - (NewsRx.com & NewsRx.net) -- Hypoxia-inducible factor-1 alpha alters tumor sensitivity to chemotherapy through DNA repair.
According to a study from Germany, "tumor hypoxia negatively regulates cell growth and causes a more malignant phenotype by increasing the expression of genes encoding angiogenic, metabolic and metastatic factors. Of clinical importance, insufficient tumor oxygenation affects the efficiency of chemotherapy and radiotherapy by poorly understood mechanisms. The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes and HIF-1 is constitutively upregulated in several tumor types."
...