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Article: New cationic lipids with photocleavable spacers enhance transfection efficiency.
- Article from:
- Gene Therapy Weekly
- Article date:
- July 17, 2003
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2003 JUL 17 - (NewsRx.com & NewsRx.net) -- New cationic lipids with photocleavable spacers enhance transfection efficiency.
According to published research from Japan, "new cationic lipids having an o-nitrobenzyl moiety as a photocleavable spacer between its hydrophilic and hydrophobic region were synthesized. To improve the efficiency of transfection with lipoplexes, after transfecting the cationic lipid aggregate/DNA complex, photoirradiation was performed."
"Photochemical decomposition of lipids would not only make the vector's membrane unstable to facilitate the fusion with endocytic vesicles, but also promote dissociation of cationic lipid-DNA ...