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Article: Hypothalamic arcuate nucleus predicts anorectic actions of leptin.
- Article from:
- Drug Week
- Article date:
- July 25, 2003
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2003 JUL 25 - (NewsRx.com & NewsRx.net) -- Activation of the hypothalamic arcuate nucleus predicted the anorectic actions of ciliary neurotrophic factor and leptin in lean and obese mice.
According to a study from the United States, "Similar to leptin, ciliary neurotrophic factor (CNTF) suppresses appetite and selectively reduces body fat in leptin-deficient ob/ob mice. To assess the relative importance of specific regions of the hypothalamus in mediating these effects, we administered a CNTF analogue (CNTF[subscript]Ax15) or leptin to mice made obese by administration of gold thioglucose (GTG), which destroys a well-defined portion of the medial basal ...