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Article: Hypoxia-inducible factor-1 alpha is implicated in stromal gastric cancers.
- Article from:
- Health & Medicine Week
- Article date:
- August 4, 2003
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2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Hypoxia-inducible factor-1 alpha is implicated in stromal gastric cancers.
According to a study from Japan, "hypoxia inducible factor (HIF)-1 is reported to transactivate expression of vascular endothelial growth factor (VEGF), which is an important angiogenic factor. The aim of this study was to elucidate the clinical significance of HIF-1alpha expression in gastrointestinal stromal tumors (GIST). Specimens obtained from 53 patients who underwent surgical resection for GIST of the stomach were used in this study."
"Specimens were examined immunchistochemically for HIF-1alpha, VEGF, and Ki-67 expression. Tumor ...