Article: TP53 and other unidentified genetic alterations may contribute to tumorigenesis.

2003 AUG 4 - (NewsRx.com & NewsRx.net) -- TP53 and other unidentified genetic alterations may contribute to tumorigenesis.

"Gliomatosis cerebri (GC) is a rare glial neoplasm with extensive diffuse brain infiltration but relative preservation of the underlying architecture," researchers in the United States report.

"Previous molecular studies, mostly analyzing biopsy samples, have suggested an astrocytic origin of GC, but a larger collective of autopsy tissue has not been investigated so far. Furthermore, whether the widespread neoplastic infiltration is based on a monoclonal process is still a matter of debate," wrote C. Mawrin and colleagues, Walter ...

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