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Article: Molecular epidemiology of O139 vibrio cholerae: mutation, lateral gene transfer, and founder flush. (Research).
- Article from:
- Emerging Infectious Diseases
- Article date:
- July 1, 2003
- Author:
CopyrightCOPYRIGHT 2003 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Vibrio cholerae in O-group 139 was first isolated in 1992 and by 1993 had been found throughout the Indian subcontinent. This epidemic expansion probably resulted from a single source after a lateral gene transfer (LGT) event that changed the serotype of an epidemic V. cholerae O1 El Tor strain to O139. However, some studies found substantial genetic diversity, perhaps caused by multiple origins. To further explore the relatedness of O139 strains, we analyzed nine sequenced loci from 96 isolates from patients at the Infectious Diseases Hospital, Calcutta, from 1992 to 2000. We found 64 novel alleles distributed among 51 sequence types. LGT events produced three times the ...
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... ... Cholera caused by either Vibrio cholerae O1 or O139 is endemic ... ElTor - Inaba - Ogawa - Vibrio cholerae O1 - O139 Vibrio cholerae O1 biotype El Tor was ... cases to Mharishi Valmiki Infectious Diseases Hospital (MVIDH) for ...
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