Article: Defining alcohol-related phenotypes in humans: the collaborative study on the genetics of alcoholism.

The Collaborative Study on the Genetics of Alcoholism (COGA) is an innovative, large-scale, multidisciplinary research program launched by the National Institute on Alcohol Abuse and Alcoholism to investigate the genetic components that contribute to the development of alcohol abuse and dependence. The study--which involves 9 research centers located across the United States--relies primarily on DNA samples, questionnaires, electrophysiological measurements, and other data obtained from nearly 3,000 people from families with at least 3 alcoholic members. Dr. Laura Jean Bierut and her colleagues describe the genetic analyses conducted on these DNA samples in an effort to ...

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