Article: Genetic therapy: just a nasal spray away? (genetic treatment for some inherited respiratory diseases)

Genetic therapy: Just a nasal spray away?

A genetic treatment for some inherited respiratory diseases could one day come packaged in the form of a nasal spray.

U.S. researchers, collaborating with two teams in France, have developed genetically engineered cold viruses that can serve as Trojan horses, carrying healthy genes into genetically defective lung cells. They now report using a tailor-made cold virus to insert a normal human gene into the lungs of rats.

Study director Ronald G. Crystal says he hopes eventually to treat patients with cystic fibrosis or other inherited lung problems by spraying the engineered virus into their nasal passages. ...

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