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Article: Interferon-gamma receptor gene mutation linked to allergic disease.
- Article from:
- Immunotherapy Weekly
- Article date:
- September 10, 2003
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2003 SEP 10 - (NewsRx.com & NewsRx.net) -- A mutation in an interferon-gamma receptor gene has been linked to allergic disease developement.
In a recent study, scientists in Japan "identified a novel heterozygous single-nucleotide substitution 1400 T-->C (Leu 467 Pro) in the seventh exon of the interferon-gamma receptor 1 (IFNGR1) gene."
"This substitution was detected in six of the 89 allergic patients but not in the 72 non-allergic subjects," noted M. Aoki and coauthors at Gifu University.
"There was a difference in the L467P frequency between the allergic patients and the non-allergic subjects (Fisher's exact test: p=0.033)," they wrote in ...