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Article: RhoA mDia is involved in actin polymerization and T lymphocyte migration.
- Article from:
- Immunotherapy Weekly
- Article date:
- September 17, 2003
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2003 SEP 17 - (NewsRx.com & NewsRx.net) -- RhoA effector mDia is involved in regulation of actin polymerization and T lymphocyte migration but not cell shape.
"Regulation of actin polymerization is critical for many different functions of T lymphocytes, including cell migration. Here we show that the RhoA effector mDia is induced in vitro in activated PBL and is highly expressed in vivo in diseased tissue-infiltrating activated lymphocytes," scientists in Spain report.
"The mDia localizes at the leading edge of polarized T lymphoblasts in an area immediately posterior to the leading lamella, in which effector protein profilin is also concentrated. ...