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Article: Philadelphia chromosome may be involved in bone marrow suppression.
- Article from:
- Cancer Gene Therapy Week
- Article date:
- September 29, 2003
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2003 SEP 29 - (NewsRx.com & NewsRx.net) -- Philadelphia chromosome may be involved in bone marrow suppression.
According to published research from Japan, "We describe a patient who presented with aplastic anemia associated with the Philadelphia (Ph-1) chromosome during immunosuppressive therapy, and who subsequently developed myelodysplastic syndrome (MDS) with monosomy 7.
"Initially, the patient had hypocellular fatty marrow without leukemic blasts or dysplastic features. Chromosome analysis showed 46, XY, t(9;22)(q34;q11) during immunosuppressive therapy, but no leukemic transformation was detected. The patient showed gradual hematologic improvement ...