|
|
Article: Aberrant somatic hypermutation linked to AIDS-associated NHL development.
- Article from:
- Biotech Week
- Article date:
- October 15, 2003
CopyrightCOPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2003 OCT 15 - (NewsRx.com & NewsRx.net) -- Aberrant somatic hypermutation may play a key role in the development of AIDS-associated NHL.
"The pathogenesis of AIDS-related non-Hodgkin lymphomas (AIDS-NHLs) is associated with chromosomal translocations that deregulate the expression of various oncogenes," researchers in New York noted. "Recently, a novel mechanism of genetic lesion, termed aberrant hypermutation, has been identified in diffuse large B-cell lymphoma (DLBCL) of immunocompetent hosts."
"In these tumors, the somatic hypermutation (SHM) process that normally targets immunoglobulin V (IgV) genes in B cells appears to misfire and causes ...