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Article: Glomerular cells, infiltrating neutrophils undergo apoptosis in lupus nephritis.
- Article from:
- Immunotherapy Weekly
- Article date:
- October 15, 2003
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2003 OCT 15 - (NewsRx.com & NewsRx.net) -- Lupus nephritis patients with autoantibodies are found to have a high level of apoptosis occurring in renal glomerular cells and infiltrating neutrophils.
"Disturbed apoptosis is proposed to be involved in the pathogenesis of systemic lupus erythematosus. However, the role of renal cell apoptosis in the pathogenesis and progression of human lupus nephritis is still controversial. We have investigated glomerular cell apoptosis and the clinicopathological relationship between apoptosis and immunoserological or histological findings in 22 patients with lupus nephritis using electron microscopy and the TdT-mediated ...