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Article: Celiac disease is complex, involving genetic and nongenetic input to form.
- Article from:
- Immunotherapy Weekly
- Article date:
- October 22, 2003
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2003 OCT 22 - (NewsRx.com & NewsRx.net) -- Celiac disease is now seen as linked to HLA-DQ2, HLA-DQ8, and yet requiring more events involving tissue transglutaminase and gliadin peptides, as well as prolamins, in order for disease to develop.
"Since the discovery of prolamins (wheat, rye, barley, and oats) as inducers of celiac disease, additional components of the celiac disease pathogenesis have been identified. Villous atrophy of the duodenal mucosa and serology of celiac disease became essential parameters in the diagnosis of celiac disease. Recently, the HLA-DQ2 and HLA-DQ8 dependency of celiac disease has been described, while it is not known why the ...