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Article: C-src plays an important role in skin tumor promotion.
- Article from:
- Cancer Vaccine Week
- Article date:
- October 20, 2003
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2003 OCT 20 - (NewsRx.com & NewsRx.net) -- C-src plays an important role in skin tumor promotion.
According to a study from the United States, "In this study, we generated transgenic mice that overexpressed either a constitutively active human c-src mutant (src(530)) or a wild-type human c-src (src(wt)) in epidermal basal cells driven by human keratin 14 (HK14) or bovine keratin 5 (BK5) promoters, respectively.
"HK14.src(530) transgenic mice developed severe epidermal hyperplasia and hyperkeratosis, and did not survive beyond 3 weeks of age. Four transgenic founders were obtained after injection of a BK5.src(wt) construct with variable phenotypes, and ...