Article: Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice.

Summary

The purpose of this study was to determine the underlying mechanism of the hypoglycemic activity of the aqueous extract perfusion of Spergularia purpurea (SP) in diabetic mice and streptozotocin-induced diabetic rats. The aqueous extract was administered intravenously and the blood glucose levels were determined within 4 hours after starting the treatment. Plasma insulin concentrations and endogenous glucose production were also determined.

The aqueous extract at a dose of 10 mg/kg produced a significant decrease in blood glucose levels in normal rats (P

We conclude that aqueous extract perfusion of SP inhibits endogenous glucose production in ...

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