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Article: Erythrocyte G protein-coupled receptor signaling involved in malaria infection.
- Article from:
- Immunotherapy Weekly
- Article date:
- October 29, 2003
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2003 OCT 29 - (NewsRx.com & NewsRx.net) -- Erythrocyte G protein-coupled receptor signaling plays a key role in malaria infection.
"Erythrocytic mechanisms involved in malarial infection are poorly understood," scientists in Chicago noted.
In a recent study, T. Harrison and colleagues at Northwestern University found that "signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (Galphas) regulated the entry of the human malaria parasite Plasmodium falciparum."
"Agonists that stimulate cyclic adenosine 3', 5'-monophosphate production led to an increase in malarial infection that could be ...