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Article: Nucleoside antimetabolites influence the steady state of HCV replicons.
- Article from:
- Health & Medicine Week
- Article date:
- November 10, 2003
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2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Nucleoside antimetabolites influence the steady state of HCV replicons.
"Treatment with antimetabolites results in chemically induced low nucleoside triphosphate pools and cell cycle arrest in exponentially growing cells. Since steady-state levels of hepatitis C virus (HCV) replicon RNA were shown to be dependent on exponential growth of Huh-7 cells, the effects of antimetabolites for several nucleoside biosynthesis pathways on cell growth and HCV RNA levels were investigated," said a study team in the United States.
"A specific anti-HCV replicon effect was defined as
i) minimal interference with the ...