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Article: LT beta R is essential for proper thymic function and autoimmune control.
- Article from:
- Proteomics Weekly
- Article date:
- November 10, 2003
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2003 NOV 10 - (NewsRx.com & NewsRx.net) -- LT beta R is essential for lymphoepithelial crosstalk, medullary epithelial cell development, and controlling autoimmunity.
According to published research from Germany, "Thymocytes depend on the interaction with thymic epithelial cells for the generation of a diverse, nonautoreactive T cell repertoire. In turn, thymic epithelial cells acquire their 3-dimensional cellular organization via instructive signals from developing thymocytes. The nature of these signals has been elusive so far.
"We show that thymocytes and medullary epithelial cells (MECs) communicate via the lymphotoxin beta receptor (LTbetaR) ...