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Article: Psoriasis unresponsive to topical corticosteroids improvised with high concentration tacalcitol ointment.(Washington Whispers)(Author Abstract)
- Article from:
- Journal of Drugs in Dermatology
- Article date:
- April 1, 2003
CopyrightCOPYRIGHT 2003 Journal of Drugs in Dermatology, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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In this prospective, multicenter, open-label non-controlled study, the use of high concentration (20[micro]g/g) tacalcitol ointment was tested in psoriasis that had previously been unresponsive to topical corticosteroids. Tacalcitol is one of the active vitamin D3 analogs. Conventional preparations of tacalcitol currently available include 2 [micro]g/g of ointment, cream, and scalp solution in Japan, and 4 [micro]g/g of ointment in European countries. However, the 20 [micro]g/g dose is still currently in clinical trials.
The study cohort included 82 patients in 31 hospitals in Japan. Patients with psoriatic lesions that had shown low or no response to ...