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Article: KChIPs help determine molecular properties of Kv4.2 potassium channels.
- Article from:
- Proteomics Weekly
- Article date:
- November 17, 2003
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2003 NOV 17 - (NewsRx.com & NewsRx.net) -- KChIPs play a fundamental role in determining the molecular properties and trafficking of Kv4.2 potassium channels.
"Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes. Co-expression of EF hand-containing Ca[superscript]2+-binding proteins termed KChIPs with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents. Here we show that KChIPs profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits," investigators in the United States report.
"Coexpression of KChIPs1-3 causes a dramatic redistribution of Kv4.2, ...