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Article: Triamcinolone acetonide has been shown to decrease both cellular proliferation and collagen production by dermal fibroblasts.(Washington Whispers)(Brief Article)
- Article from:
- Journal of Drugs in Dermatology
- Article date:
- December 1, 2002
CopyrightCOPYRIGHT 2002 Journal of Drugs in Dermatology, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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This study looked at the effects of triamcinolone acetonide on normal human and keloid dermal fibroblasts in vitro.
Normal human fibroblasts and keloid dermal fibroblasts were exposed in vitro to increasing amounts of triamcinolone acetonide. Cell counts, levels of bFGF and TGF-betal in the supernatants were then measured.
20 micromolar triamcinolone acetonide caused a significant increase in bFGF for normal and keloid fibroblast cell lines. It also caused a significant decreases in the level of TGF-beta1 for normal and keloid fibroblast cell lines. ...