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Article: Peripheral benzodiazepine receptor ligands appear to benefit pneumopathy.
- Article from:
- Blood Weekly
- Article date:
- November 27, 2003
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2003 NOV 27 - (NewsRx.com & NewsRx.net) -- Peripheral benzodiazepine receptor ligands appear to benefit pneumopathy, may help in Lupus; localize to leukocytes and bronchial epithelial Clara cells in an animal model.
"In this study, we documented the effects of the different peripheral benzodiazepine receptor (PBR) ligands PK 11195, Ro5-4864, and the newly described SSR 180575 on the development of pulmonary inflammation in vivo. To this aim, we used MRL/lpr mice that develop pathological signs similar to the human lupus erythematosus (LE) signs," scientists writing in the journal Immunology Letters report.
"We found that a chronic treatment (at 3 mg/kg ...