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Article: Pentostatin appears to induce safe lymphodepletion for stem-cell transplant.
- Article from:
- Health & Medicine Week
- Article date:
- November 24, 2003
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2003 NOV 24 - (NewsRx.com & NewsRx.net) -- Pentostatin appears to induce safe lymphodepletion for nonmyeloablative allogeneic stem-cell transplantation.
"Nonmyeloablative allogeneic stem-cell transplantation (alloNST) is the focus of investigations searching for less toxic transplantation regimens. We report studies on the kinetics of lymphodepletion and safety of pentostatin (PT) conditioning in alloNST," researchers in the United States report.
"Patients with hematologic malignancy received mobilized blood from human leukocyte antigen (HLA)-matched related (n=4) or unrelated (n=8) donors. PT 4 mg/m[superscript]2 was administered on days -21, -20, and ...