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Article: Sulodexide shows promise in the treatment of oral erosive/ulcerative lichen planus.(Washington Whispers)(Brief Article)
- Article from:
- Journal of Drugs in Dermatology
- Article date:
- June 1, 2003
CopyrightCOPYRIGHT 2003 Journal of Drugs in Dermatology, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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This open non-randomized trial compared the effect of heparinoid sulodexide systemically compared with topical cyclosporine on chronic oral erosive/ulcerative lichen planus. Sulodexide is composed of 80% heparin and 20% dermatan sulfate. Preliminary studies have shown that low molecular weight heparin may produce partial resolution of lichen planus with cutaneous and oral involvement.
Twenty patients were non-randomly divided into two subgroups, with each group having comparable numbers of men/women, HCV status, and oral lesions of comparable pain and extent. The sulodexide group received intramuscular treatment (600 units) once, followed by oral doses of 250 ...