|
|
Article: Up-regulation of MMP-9 occurs in skin lesions related to Lyme disease.
- Article from:
- Drug Week
- Article date:
- December 12, 2003
CopyrightCOPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2003 DEC 12 - (NewsRx.com & NewsRx.net) -- Selective up-regulation of matrix metalloproteinase-9 (MMP-9) expression occurs in human erythema migrans skin lesions resulting from acute Lyme disease.
According to recent research published in the Journal of Infectious Diseases, "Despite the absence of enzymes that digest extracellular matrix, Borrelia burgdorferi spreads in the skin to form erythema migrans (EM) lesions and then disseminates to other organs. We studied the induction by bacteria of host matrix metalloproteinases (MMPs) in EM skin lesions of patients with acute Lyme disease."
"In blister fluid from the EM lesions, the expression of MMP-9 was ...