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Article: Heparin cofactor II, antithrombin III have separate localization in skin wounds.
- Article from:
- Medical Devices & Surgical Technology Week
- Article date:
- December 14, 2003
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2003 DEC 14 - (NewsRx.com & NewsRx.net) -- Heparin cofactor II, antithrombin III are serpins with separate localization in acute and healing skin wounds.
According to recent research from the United States, "the physiologic function of the serpin heparin cofactor II (HCII) is not fully understood. We have hypothesized that HCII functions as an extravascular inhibitor of thrombin. Thrombin formed at a site of injury has been hypothesized to contribute to migration and proliferation of fibroblasts and smooth muscle cells involved in wound healing.
"To begin to test our hypothesis, we examined the immunohistochemical localization of HCII in human skin, and ...