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Article: Sodium hydroxide renders prion protein sensitive to proteinase K.
- Article from:
- Biotech Week
- Article date:
- December 17, 2003
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2003 DEC 17 - (NewsRx.com & NewsRx.net) -- Sodium hydroxide renders the prion protein PrP[superscript]Sc sensitive to proteinase K.
According to recent research published in the Journal of General Virology, "Sodium hydroxide (NaOH) solutions are widely used for the purification of contaminated equipment, as they are known to inactivate a variety of pathogens. However, information about their effect on agents causing transmissible spongiform encephalopathy (TSE) is sparse and contradictory."
"Scrapie hamster brain homogenate, containing the disease-associated form of the prion protein (PrP[superscript]Sc), was exposed to NaOH," said Fabian Kasermann and ...