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Article: Prenatal PCB exposure, the corpus callosum, and response inhibition.(Children's Health)
- Article from:
- Environmental Health Perspectives
- Article date:
- October 1, 2003
- Author:
CopyrightCOPYRIGHT 2003 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The present study reports the association between prenatal exposure to polychlorinated biphenyls (PCBs), the corpus callosum, and response inhibition in children who are 4.5 years old. Children (n = 189) enrolled in the Oswego study were tested using a continuous performance test. We measured (square millimeters) the splenium of the corpus callosum, a pathway implicated in the regulation of response inhibition, using magnetic resonance imaging. Results indicated a dose-dependent association between cord blood PCBs and errors of commission. Splenium size but not other brain areas predicted errors of commission ([r.sup.2] = 0.20), with smaller size associated with more ...
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