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Article: Molecular mechanisms of allergic disease.(Featured CME Topic: Allergy)
- Article from:
- Southern Medical Journal
- Article date:
- November 1, 2003
- Author:
CopyrightCOPYRIGHT 2003 Southern Medical Association. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Abstract: Interaction of allergen with T-cells is associated with patterns of cytokine release by immunocompetent cells characterized as T-helper Th1 or Th2 T-immune responses. The Th2 pattern of inflammation induced by this cytokine release is associated with allergic diseases. The molecular mechanisms underlying allergic inflammation are the signals for immunoglobulin (Ig) E production and the activation of mast cells and eosinophils. Data suggesting that environmental exposure may play a role in the induction of the Th2 pattern of inflammation has led to the development of the "hygiene hypothesis." Knowledge of the mechanisms of allergic inflammation has allowed the ...
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Article: Abgenix and Sosei to Codevelop Antibodies against Allergic ...
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... ... human monoclonal antibody therapies against a promising allergic inflammation target. The target, CRTH2, is a receptor expressed ... manufacturing capabilities, to explore a promising target for allergic inflammation," said Ray Withy, Ph.D., president and chief executive ...
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