Article: Allergic and nonallergic drug reactions.(Featured CME Topic: Allergy)

Abstract: Allergic drug reactions may be difficult to distinguish from nonallergic reactions. In this article, we review a pragmatic approach to the management of adverse drug reactions on the basis of knowledge of the classification and patterns of these reactions. Algorithms for management of patients with a previous adverse drug reaction who require treatment for the same indication, and the approach to a patient who experiences a drug reaction while on multiple drugs, are presented.

Key Words: anaphylaxis, drug reaction, hypersensitivity syndrome

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Most adverse drug reactions (ADRs) are not truly allergic in nature. Immunoglobulin (Ig) E-mediated drug ...

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