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Article: Antigenic spacer domains in ADAMS-13 are needed to cut von Willebrand factor.
- Article from:
- Genomics & Genetics Weekly
- Article date:
- January 2, 2004
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2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Cysteine-rich spacer domains in ADAMS-13 are needed to cut von Willebrand factor, but are the antigenic portion if autoantibodies occur.
According to a study from Japan, "a severe lack of von Willebrand factor-cleaving protease (VWF-CP) activity can cause thrombotic thrombocytopenic purpura (TTP). This protease was recently identified as a member of the ADAMTS family, ADAMTS-13.
"It consists of a pre-proregion, a metalloprotease domain, a disintegrin-like domain, a thrombospondin type-1 motif (Tsp1), a cysteine-rich domain, a spacer domain, additional Tsp1 repeats, and CUB domains.
"To explore the ...