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Article: Multiple roles of the tuberous sclerosis complex genes reviewed.
- Article from:
- Cancer Weekly
- Article date:
- January 6, 2004
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2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Researchers summarize some current concepts in the understanding of the biological and biochemical function of the TSC genes.
According to recent research from the United States, "Soon after proposing the ''two-hit'' hypothesis for tumorigenesis, Knudson pursued further experimental validation of the concept by using a rat model of dominantly inherited renal tumor.
"Today, the Eker rat is one of the best characterized models of tuberous sclerosis complex (TSC) and has been used extensively for study of the function of the TSC2 tumor suppressor gene," wrote R.S. Yeung and colleagues, University of Washington, ...