Article: Request for information about acute encephalopathy associated with influenza virus infection in U.S. children.(Notice to Readers)(Brief Article)

Since the mid-1990s, several hundred cases of acute encephalopathy have been reported in Japanese children with influenza virus infection (1,2). These cases have been characterized by fever and rapid onset of encephalopathy, resulting in a high frequency of neurologic sequelae and mortality. The majority of the children have had laboratory-confirmed evidence of influenza.

Reports of influenza-associated encephalopathy have been uncommon in the United States (3,4). To determine if a similar pattern is occurring in the United States, CDC is requesting information on any case meeting certain criteria. The criteria include a person aged <18 years with altered mental status or personality change lasting>24 hours and occurring within ...

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