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Article: Influenza virus envelope cholesterol is required for virus entry, infectivity.
- Article from:
- Biotech Week
- Article date:
- January 21, 2004
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2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Influenza virus envelope cholesterol is required for virus entry, infectivity.
"Enveloped viruses are highly dependent on their lipid envelopes for entry into and infection of host cells. Here, we have examined the role of cholesterol in the virus envelope, using methyl-beta-cyclodextrin depletion," investigators in the United States report.
"Pretreatment of virions with methyl-beta-cyclodextrin efficiently depleted envelope cholesterol from influenza virus and significantly reduced virus infectivity in a dose-dependent manner. A nonenveloped virus, simian virus 40, was not affected by methyl-beta-cyclodextrin ...