Article: Approach to unnatural insertion of amino acids into proteins proposed.

2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Scientists present a possible approach to two different unnatural site-specific insertion of amino acids into proteins in mammalian cells via nonsense suppression.

"The site-specific insertion of an unnatural amino acid into proteins in vivo via nonsense suppression has resulted in major advances in recent years. The ability to incorporate two different unnatural amino acids in vivo would greatly increase the scope and impact of unnatural amino acid mutagenesis," scientists writing in the journal Chemistry and Biology report.

"Here, we show the concomitant suppression of an amber and an ochre codon in a single ...

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