Article: Cellular sodium and calcium levels are vital to skeletal muscle physiology.

2004 FEB 8 - (NewsRx.com & NewsRx.net) -- Intracellular calcium levels are essential to physiologic signaling processes such as the transmission of signals between synapses in nerve cells and muscle excitation and contraction.

Ncx3, a sodium/calcium exchanger is able to regulate cellular calcium levels by controlling calcium import and export at the plasma membrane. In order to elucidate the physiologic role of Ncx3 in skeletal muscle, Sophie Sokolow and colleagues from Universite Libre de Bruxelles, Belgium, generated mice lacking the Ncx3 gene. Their report in the Journal of Clinical Investigation described the observation in these mice of localized muscle ...

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