Article: Keratin polypeptide gene deletions heighten susceptibility to liver injury.

2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Keratin polypeptide gene deletions in mice heighten susceptibility to liver injury.

According to published research from the United States, "keratin transgenic mouse models and the association of human keratin mutations with liver disease highlight the importance of keratins in protecting the liver from environmental insults, but little is known regarding keratins and their function in the gallbladder. We characterized keratin expression pattern and filament organization in normal and keratin polypeptide-8 (K8)-null, K18-null and K19-null gallbladders, and examined susceptibility to liver and gallbladder injury induced by ...

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