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Article: Vitamin B12 injections for tiredness.(Literature Review & Commentary)
- Article from:
- Townsend Letter for Doctors and Patients
- Article date:
- February 1, 2004
- Author:
CopyrightCOPYRIGHT 2004 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Twenty-eight individuals complaining of fatigue completed a double-blind crossover trial of vitamin B12 injections. Prior to the study, all subjects had normal levels of hemoglobin and vitamin B12. Hydroxocobalamin (5 mg intramuscularly, twice a week for 2 weeks) was followed by a 2-week washout period, and then a similar course of placebo injections. In about half of the participants, placebo injections were given first. Those who received placebo first had a significant response to vitamin B12 in terms of general well being (p = 0.006) and happiness (p = 0.032). Improvements in fatigue (p = 0.09) and appetite (p = 0.073) due to vitamin B12 were of borderline statistical ...
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