Article: Vitamin C for luteal phase defect.(Literature Review & Commentary)

One hundred-fifty infertile women (mean age, 35 years) with luteal phase defect were randomly assigned to a control group or to receive 750 mg/day of ascorbic acid, beginning on the first day of a menstrual cycle and continuing until pregnancy was achieved, or for a maximum of 6 months. The progesterone level increased in 53% of the women receiving vitamin C and in 22% of controls (p

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Comment: Luteal phase defect is a common disorder associated with infertility and spontaneous miscarriage. Inadequate maturation and development of the endometrium is seen in this condition; this abnormality is believed to be due to insufficient progesterone ...

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