Article: Salvinal has antimitotic activity in drug-resistant human tumor cells.

Article: Salvinal has antimitotic activity in ...
Drug Week;  March 12, 2004 ;     700+ words ... ... NewsRx.net) -- Salvinal, a novel microtubule ... Danshen), possesses antimitotic activity in multidrug-sensitive ... glycoprotein and MRP. Salvinal may be useful in the ... Molecular Pharmacology (Salvinal, a novel microtubule ... Danshen), with antimitotic activity in ...

Article: Biological assay and antimitotic activity of novel ...
Indian Journal of Pharmaceutical Sciences;  January 1, 2007 ;     700+ words ... ... Basavaraju, B. Sadashivamurthy Antimitotic activity of new synthetic analogues benzyl ... present work showed strong to moderate antimitotic activity. They might bind to the critical ... ethylenedioxy group in (3) on the antimitotic activity. With this in view, we have synthesized ...

Article: Novel quinolones have promising antitumor activity.
Cancer Weekly;  November 23, 2004 ;     625 words ... ... group, and an unsubstituted N1 were essential for the antimitotic activity." "In accordance with the literature, a fluoro group ... published their study in the Journal of Medicinal Chemistry (Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones ...

Article: New cancer research from Kwandong University, Medical Department ...
Cancer Weekly;  July 21, 2009 ;     700+ words ... ... Biochemical Pharmacology (7-Diethylamino-3(2'-benzoxazolyl)-coumarin is a novel microtubule inhibitor with antimitotic activity in multidrug resistant cancer cells. Biochemical Pharmacology, 2009;77(12):1773-1779). For more ...

Article: Total synthesis of novel dictyostatin analogs and hybrids as ...
Pure and Applied Chemistry;  February 1, 2009 ;     700+ words ... ... problem in the clinic. This has led to the search for novel microtubule-stabilizing agents that have similar antimitotic activity to the taxanes, but lack the interaction with P-glycoprotein or bind to unique sites on tubulin [4]. Discodermolide ...

Article: New glioma research from I. Garciaalvarez and co-researchers ...
Cancer Weekly;  May 12, 2009 ;     560 words ... ... The synthetic glycoside, oleyl N-acetyl-alpha-D-glucosaminide(1), was previously shown to exhibit antimitotic activity on rat (C6) and human (U-373) glioma lines. To obtain information about its mechanism of action, metabolite ...

Article: Potato disc tumor induction assay: a multiple mode of drug action ...
Phytomedicine: International Journal of Phytotherapy & Phytopharmacology;  March 1, 2003 ;     700+ words ... ... The inhibition of A. tumefaciens-induced tumors (or Crown Gall) in potato disc tissue is an assay based on antimitotic activity and can detect a broad range of known and novel antitumor effects (McLaughlin and Rogers, 1998). Crown Gall ...